Custom Peptides
Cayman Chemical DIbutyrylCyclIc GMPsodIum 10mg
A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase
Cayman Chemical 14-DeoxyndrographolIde 10mg
A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 UG/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model
Cayman Chemical Fenoldopamesylate 10mg
An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively); alters hemodynamic properties, including hypertension, in animals.
Cayman Chemical SumnIrolemaleate 10mg
A dopamine D2 receptor agonist; selective for D2 over D1, D3, and D4 receptors (Kis = 9.0, >7,140, 1,940, and >2,190 nM, respectively); inhibits forskolin-stimulated cAMP accumulation in CHO cells expressing human recombinant D2A receptors (EC50 = 17 nM); decreases plasma prolactin levels in rats at ≥3.1 µmol/kg; inhibits dopamine neuron firing in the SNPC in anesthetized rats (ED50 = 2.3 µmol/kg); increases horizontal locomotor activity in a reserpinized, AMPT rat model of Parkinson's disease at ≥12.5 µmol/kg; decreases time spent in the open arms of the elevated plus maze and time spent immobile in the forced swim test in mice with SNPC lesions at 0.1 mg/kg; reduces premature responding by rats in the 5CRTT compared with untreated animals at ≥0.1 mg/kg
Cayman Chemical INCB 3284dImesylate 10mg
A potent, selective, and orally bioavailable antagonist of MCP-1 binding to CCR2 (IC50 = 3.7 nM); inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees
Cayman Chemical 2 5-dIdeoxy AdenosIn 10mg
A cell-permeable, P-site inhibitor of adenylate cyclase; inhibits forskolin-induced activation of a cAMP-dependent reporter gene in HEK293 cells with an IC50 value of 33 µM
Cayman Chemical UR144 N 5bromopentyl nal 10mg
Differs from UR-144 by having a bromine atom on the terminal carbon of the alkyl group; intended for research and forensic applications
Cayman Chemical JWH 203 4CLOrophenl IsomR 10mg
An analytical reference standard categorized as a synthetic cannabinoid; reduces spontaneous locomotor activity, but does not induce antinociception or a decrease in body temperature, in mice; intended for research and forensic applications
Cayman Chemical TASP0277308 10mg
An S1P1 antagonist (IC50 = 4.2 nM); selective for S1P1 over S1P3, S1P4, and S1P5 (IC50s = >10,000, >10,000, and 8,756 nM, respectively); inhibits S1P-induced [35S]GTPγS binding and forskolin-induced cAMP production in HEK293 cells expressing human S1P1 (IC50s = 7.8 and 4.3 nM, respectively); inhibits S1P-induced migration of CHO cells expressing human S1P1 (IC50 = 18 nM); induces lymphopenia in mice at 100 mg/kg; reduces bone erosion in a mouse model of collagen-induced arthritis; intrathecal administration reduces flinching and guarding behaviors in a mouse model of cancer-induced bone pain at 3 or 10 nmol/animal
Cayman Chemical -NorepInphrIn-d6hydroc 10mg
An internal standard for the quantification of norepinephrine by GC- or LC-MS
Cayman Chemical 1ArachIdoyl2Oleoyl3PalmI 10mg
A triacylglycerol; has been found in a variety of plant oils, including poppy seed, hazelnut, maize, olive, yellow melon, and date seed oils
Cayman Chemical 1ArachIdoyl2PalmItoyl3Ol 10mg
A triacylglycerol; has been found in butterfat; levels are increased in Plin5-overexpressing mice fed a high-fat diet
Cayman Chemical 2MethoxymethcathInonhydro 10mg
A positional isomer of methedrone, having the methoxy group at the 2 rather than the 4 position; intended for forensic and research applications
Cayman Chemical 3MethoxymethcathInonhydro 10mg
A positional isomer of methedrone, having the methoxy group at the 3 rather than the 4 position; intended for forensic and research applications